I wrote about the TB drug back in December: https://healingnumenor.wordpress.com/2008/12/10/tuberculosis-medication-shortage/.
I wish I could report the situation was improving. In fact, it has worsened. Yesterday, one of the doctors mentioned at a research meeting that the drugs were out in the National TB/Leprosy Control Programme (NTLP). Some of our doctors have dual roles in our research center and at the NTLP. Our research participants have access to medications. However, most TB patients are not enrolled in studies.
I’ll briefly explain the regimens and then the shortages.
TB medications: S=streptomycin; E=ethambutol; H=INH; R=rifampin; Z=pyrazinamide
New TB patients get either: (1) 2 months E+H+R+Z then 4 months H+R; or (2) 2 E+H+R+Z then 6 months H+E.
Retreatment TB cases typically get: 2 months S+E+H+R+Z then 1 month E+H+R+Z then 5 months E+H+R.
Mulago Hospital TB Wards 5&6/NTLP Clinic see about 25% of the nation’s TB burden and about 200-250 TB patients per month. The shortage is especially worse in Kampala then in some rural areas. (We’re ranked 16th in the world for TB burden in the 202/212 countries that report TB cases.)
As of this morning we had:
(1) NO R+H+E formulation for pediatric TB patients.
(2) 2-month initial phase of E+H+R+Z for only 12 patients.
(3) Only 15 one-month boxes of E+H+R for the retreatment TB cases.
(4) Hundreds of H+E but…..they were all expired.
(5) 1300 vials of streptomycin. However, given that it would have to be taken with E+H+R+Z (see #2 above) in the retreatment regimen, the surplus is of practically no use.
Later in the day, I found out that the Daily Monitor had a blame-game story on this: http://www.monitor.co.ug/artman/publish/news/Uganda_in_TB_drugs_shortage_81681.shtml.
I’m not in the position or have the knowledge to offer more on who is at fault than the story does, but off the record I have some hunches. Anyhow, the focus needs to be on the solution and future prevention of shortages as numbers of patients continue to suffer.
I emailed two human rights organizations after my tour of the NTLP pharmacy with one of the doctors and the pharmacist there. Tomorrow morning I am going to the NTLP clinic to see what it is going to be like to tell patients they have TB but that we can’t give them the medications. Tomorrow afternoon I am talking with a reporter and on Thursday there will be a press conference on drug shortages in general. I’ll post how these all go. Click on the comments below for an update.